2021
van der Welle REN, Jobling R, Burns C, Sanza P, van der Beek JA, Fasano A, Chen L, Zwartkruis FJ, Zwakenberg S, Griffin EF, Ten Brink C, Veenendaal T, Liv N, van Ravenswaaij-Arts CMA, Lemmink HH, Pfundt R, Blaser S, Sepulveda C, Lozano AM, Yoon G, Santiago-Sim T, Asensio CS, Caldwell GA, Caldwell KA, Chitayat D, Klumperman J. Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation. EMBO Mol Med. 2021 May 7;13(5):e13258. doi: 10.15252/emmm.202013258. Epub 2021 Apr 14. PubMed PMID: 33851776; PubMed Central PMCID: PMC8103106.
Schänzer A, Achleitner MT, Trümbach D, Hubert L, Munnich A, Ahlemeyer B, AlAbdulrahim MM, Greif PA, Vosberg S, Hummer B, Feichtinger RG, Mayr JA, Wortmann SB, Aichner H, Rudnik-Schöneborn S, Ruiz A, Gabau E, Sánchez JP, Ellard S, Homfray T, Stals KL, Wurst W, Neubauer BA, Acker T, Bohlander SK, Asensio C, Besmond C, Alkuraya FS, AlSayed MD, Hahn A, Weber A. Mutations in HID1 Cause Syndromic Infantile Encephalopathy and Hypopituitarism. Ann Neurol. 2021 Jul;90(1):143-158. doi: 10.1002/ana.26127. Epub 2021 Jun 5. PubMed PMID: 33999436; PubMed Central PMCID: PMC8351430.
2020
Burns CB , Yau B, Rodriguez A, Triplett J, Maslar D, An YS, van der Welle RE, Koscina RG, Fisher MR, Strout GW, Bayguinov PO, Veenendaal T, Chitayat D, Fitzpatrick JAJ, Klumperman J, Kebede MA, Asensio CS. Pancreatic Beta-Cell Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion. Diabetes, 2020 Nov 9, online ahead of print.
2019
Hummer B, Maslar D, Soltero Gutierrez M, de Leeuw NF, Asensio CS. Differential sorting behavior for soluble and transmembrane cargoes at the trans-Golgi network in endocrine cells. Mol Biol Cell. 2019 Dec 11.
Topalidou I, Cattin-Ortola J, Hummer B, Asensio CS, Ailion M. EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells. Molecular Biology of the Cell, 2019, Nov 13.
Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH.
Synaptic vesicle recycling pathway determines neurotransmitter content and release properties.
Neuron, 2019 Apr 19.
2018
Petrelli F, Dallérac G, Pucci L, Cali C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Knott GW, Magara F, Gertsch J, Kirchhoff F, Edwards RH, Mothet JP, Bezzi P.
Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.
Molecular Psychiatry, 2018 Aug 20.
Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.
The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.
Nature Communications, 2018 May 25.
2017
Hummer BH, de Leeuw NF, Burns CH, Chen L, Joens MS, Hosford B, Fitzpatrick JA, Asensio CS.
HID-1 controls large dense core vesicle formation by influencing cargo sorting and TGN acidification.
Mol. Bio. Cell. 2017 Oct 26. Online
2015
Asensio CS.
Application of Cas9/CRISPR to the study of synaptic function.
Med Sci (Paris). 2015 Feb;31(2):137-8. PubMed PMID: 25744259.
2014
Incontro S, Asensio CS, Edwards RH, Nicoll RA.
Efficient, complete deletion of synaptic proteins using CRISPR.
Neuron. 2014 Sep 3;83(5):1051-7. PubMed PMID: 25155957; NIHMSID: NIHMS631657; PubMed Central PMCID: PMC4195490.
2013
Asensio CS, Sirkis DW, Maas JW Jr, Egami K, To TL, et al.
Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25;27(4):425-37. PubMed PMID: 24210660; NIHMSID: NIHMS532510; PubMed Central PMCID: PMC3974617.
Sirkis DW, Edwards RH, Asensio CS.
Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.
PLoS Genet. 2013;9(9):e1003812. PubMed PMID: 24086151; PubMed Central PMCID: PMC3784564.
2012-
Asensio CS, Sirkis DW, Edwards RH.
RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010 Dec 13;191(6):1173-87. PubMed PMID: 21149569; PubMed Central PMCID: PMC3002028.
Flandin P, Lehr L, Asensio C, Giacobino JP, Rohner-Jeanrenaud F, et al.
Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism.
Endocrine. 2009 Oct;36(2):246-54. PubMed PMID: 19598006.
Asensio CS, Arsenijevic D, Lehr L, Giacobino JP, Muzzin P, et al.
Effects of leptin on energy metabolism in beta-less mice.
Int J Obes (Lond). 2008 Jun;32(6):936-42. PubMed PMID: 18283283.
Lehr L, Canola K, Asensio C, Jimenez M, Kuehne F, et al.
The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture.
FEBS Lett. 2006 Aug 21;580(19):4661-6. PubMed PMID: 16876797.
Somm E, Cettour-Rose P, Asensio C, Charollais A, Klein M, et al.
Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents. Diabetologia. 2006 Feb;49(2):387-93. PubMed PMID: 16385385.
Asensio C, Jimenez M, Kühne F, Rohner-Jeanrenaud F, Muzzin P.
The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intolerance.
Diabetes. 2005 Dec;54(12):3490-5. PubMed PMID: 16306366.
Cettour-Rose P, Theander-Carrillo C, Asensio C, Klein M, Visser TJ, et al.
Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion.
Diabetologia. 2005 Apr;48(4):624-33. PubMed PMID: 15756538.
Asensio C, Muzzin P, Rohner-Jeanrenaud F.
Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance.
Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S45-52. PubMed PMID: 15592486.
Asensio C, Cettour-Rose P, Theander-Carrillo C, Rohner-Jeanrenaud F, Muzzin P.
Changes in glycemia by leptin administration or high- fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis. Endocrinology. 2004 May;145(5):2206-13. PubMed PMID: 14962997.
Book chapters
Incontro S., Asensio C.S., Nicoll R.A. (2017)
Dissecting the Role of Synaptic Proteins with CRISPR.
In: Jaenisch R., Zhang F., Gage F. (eds) Genome Editing in Neurosciences. Research and Perspectives in Neurosciences. Springer, Cham
Schänzer A, Achleitner MT, Trümbach D, Hubert L, Munnich A, Ahlemeyer B, AlAbdulrahim MM, Greif PA, Vosberg S, Hummer B, Feichtinger RG, Mayr JA, Wortmann SB, Aichner H, Rudnik-Schöneborn S, Ruiz A, Gabau E, Sánchez JP, Ellard S, Homfray T, Stals KL, Wurst W, Neubauer BA, Acker T, Bohlander SK, Asensio C, Besmond C, Alkuraya FS, AlSayed MD, Hahn A, Weber A. Mutations in HID1 Cause Syndromic Infantile Encephalopathy and Hypopituitarism. Ann Neurol. 2021 Jul;90(1):143-158. doi: 10.1002/ana.26127. Epub 2021 Jun 5. PubMed PMID: 33999436; PubMed Central PMCID: PMC8351430.
2020
Burns CB , Yau B, Rodriguez A, Triplett J, Maslar D, An YS, van der Welle RE, Koscina RG, Fisher MR, Strout GW, Bayguinov PO, Veenendaal T, Chitayat D, Fitzpatrick JAJ, Klumperman J, Kebede MA, Asensio CS. Pancreatic Beta-Cell Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion. Diabetes, 2020 Nov 9, online ahead of print.
2019
Hummer B, Maslar D, Soltero Gutierrez M, de Leeuw NF, Asensio CS. Differential sorting behavior for soluble and transmembrane cargoes at the trans-Golgi network in endocrine cells. Mol Biol Cell. 2019 Dec 11.
Topalidou I, Cattin-Ortola J, Hummer B, Asensio CS, Ailion M. EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells. Molecular Biology of the Cell, 2019, Nov 13.
Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH.
Synaptic vesicle recycling pathway determines neurotransmitter content and release properties.
Neuron, 2019 Apr 19.
2018
Petrelli F, Dallérac G, Pucci L, Cali C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Knott GW, Magara F, Gertsch J, Kirchhoff F, Edwards RH, Mothet JP, Bezzi P.
Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.
Molecular Psychiatry, 2018 Aug 20.
Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.
The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.
Nature Communications, 2018 May 25.
2017
Hummer BH, de Leeuw NF, Burns CH, Chen L, Joens MS, Hosford B, Fitzpatrick JA, Asensio CS.
HID-1 controls large dense core vesicle formation by influencing cargo sorting and TGN acidification.
Mol. Bio. Cell. 2017 Oct 26. Online
2015
Asensio CS.
Application of Cas9/CRISPR to the study of synaptic function.
Med Sci (Paris). 2015 Feb;31(2):137-8. PubMed PMID: 25744259.
2014
Incontro S, Asensio CS, Edwards RH, Nicoll RA.
Efficient, complete deletion of synaptic proteins using CRISPR.
Neuron. 2014 Sep 3;83(5):1051-7. PubMed PMID: 25155957; NIHMSID: NIHMS631657; PubMed Central PMCID: PMC4195490.
2013
Asensio CS, Sirkis DW, Maas JW Jr, Egami K, To TL, et al.
Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25;27(4):425-37. PubMed PMID: 24210660; NIHMSID: NIHMS532510; PubMed Central PMCID: PMC3974617.
Sirkis DW, Edwards RH, Asensio CS.
Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.
PLoS Genet. 2013;9(9):e1003812. PubMed PMID: 24086151; PubMed Central PMCID: PMC3784564.
2012-
Asensio CS, Sirkis DW, Edwards RH.
RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010 Dec 13;191(6):1173-87. PubMed PMID: 21149569; PubMed Central PMCID: PMC3002028.
Flandin P, Lehr L, Asensio C, Giacobino JP, Rohner-Jeanrenaud F, et al.
Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism.
Endocrine. 2009 Oct;36(2):246-54. PubMed PMID: 19598006.
Asensio CS, Arsenijevic D, Lehr L, Giacobino JP, Muzzin P, et al.
Effects of leptin on energy metabolism in beta-less mice.
Int J Obes (Lond). 2008 Jun;32(6):936-42. PubMed PMID: 18283283.
Lehr L, Canola K, Asensio C, Jimenez M, Kuehne F, et al.
The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture.
FEBS Lett. 2006 Aug 21;580(19):4661-6. PubMed PMID: 16876797.
Somm E, Cettour-Rose P, Asensio C, Charollais A, Klein M, et al.
Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents. Diabetologia. 2006 Feb;49(2):387-93. PubMed PMID: 16385385.
Asensio C, Jimenez M, Kühne F, Rohner-Jeanrenaud F, Muzzin P.
The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intolerance.
Diabetes. 2005 Dec;54(12):3490-5. PubMed PMID: 16306366.
Cettour-Rose P, Theander-Carrillo C, Asensio C, Klein M, Visser TJ, et al.
Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion.
Diabetologia. 2005 Apr;48(4):624-33. PubMed PMID: 15756538.
Asensio C, Muzzin P, Rohner-Jeanrenaud F.
Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance.
Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S45-52. PubMed PMID: 15592486.
Asensio C, Cettour-Rose P, Theander-Carrillo C, Rohner-Jeanrenaud F, Muzzin P.
Changes in glycemia by leptin administration or high- fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis. Endocrinology. 2004 May;145(5):2206-13. PubMed PMID: 14962997.
Book chapters
Incontro S., Asensio C.S., Nicoll R.A. (2017)
Dissecting the Role of Synaptic Proteins with CRISPR.
In: Jaenisch R., Zhang F., Gage F. (eds) Genome Editing in Neurosciences. Research and Perspectives in Neurosciences. Springer, Cham